Refines wet milling with clean and sterile technology

The DYNO^®-MILL MULTI LAB CIP/SIP from WAB-GROUP^® is a specially designed agitator wet mill for sterile research and development, pilot, and production operations in the pharma industry. It can process low to high-viscous products with batch sizes starting from 500 ml. What is more, it comes with easily interchangeable grinding chambers from 0.3 l to 1.4 l. It can accommodate both, WAB KD agitator discs as well as the DYNO^®-ACCELERATOR. The use of agitating small beads in wet milling efficiently grinds suspended particles to the low micrometer or even nanometer range, maintaining a narrow particle size distribution.

Cleaning in Place (CIP) ensures there is no direct contact between the plant operator and active pharmaceutical ingredients. Steam sterilization up to 135°C ensures plant sterility, guaranteeing a germ-free production of tablets, capsules, injectables, and vaccines.

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Achieves perfect homogenization of APIs with three-dimensional mixing

TURBULA^®, a 3D shaker mixer from WAB-GROUP^®, is designed for uniformly mixing powdery substances with diverse particle sizes and specific weights. It excels in handling both wet and dry components, like powder inhalers or API.  Based on the Schatz geometric theory, its distinctive three-dimensional motion incorporates rotation, translation, and inversion. It facilitates a dynamic and harmonious mixing of the API with the carrier material. This constant, rhythmic pulsing motion of the shaker container ensures exposure to a vibrant, homogeneous mixing. Available in a range of configurations to accommodate container volumes spanning from 0.1 to 55 liters, the 3D shaker mixer proves its versatility across various pharma industries, R&D labs, as well as pharma production plants.

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Employs ultra-fine grinding for cell disruption and extraction of ingredients

DYNO^®-MILL MULTI LAB (ML) from WAB-GROUP^® is an adaptable laboratory agitator bead mill, well-suited for small-scale productions and R&D in biotechnology. Suitable in continuous and discontinuous operations, the bead mill specifically designed for smaller applications can utilize ultra-fine grinding beads as small as 0.1mm. It has adjustable grinding chamber sizes, material selection, and adaptable grinding technology. It incorporates two grinding principles in one mill: the DYNO^® agitator disc and the patented DYNO^®-ACCELERATOR.

Discontinuous operation utilizes grinding vessels of 0.15 l and 0.3 l to handle low-viscosity suspensions. The batches range from 85 ml to 170 ml. Continuous operation is suitable for processing highly fluid to viscous, pumpable products.  It employs grinding containers of 0.15, 0.3, 0.6, and 1.4 l to process batch sizes exceeding 500 ml. Using superior ceramic components such as SiC and ZrO₂ ensures no metal contamination and an extended service life.

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Controls and Transfers Powders Safely

The Sterisplit Split Butterfly Valve from Hanningfield offers a reliable solution for handling and transferring pharmaceutical, nutraceutical, and chemical powders. Designed to meet stringent cGMP and EHEDG standards, this valve features a unique two-part design, allowing for controlled powder flow while maintaining a clean external surface. Its stainless steel construction ensures durability and resistance to corrosion, while translucent silicone, EPDM, and FKM seals offer compatibility with various substances. Applications span paracetamol tablets, protein supplements, and even dangerous substances like pesticides and explosive powders. Integrating seamlessly into existing production lines, the Sterisplit supports both manual and continuous operations, ensuring precise dosing and efficient containment. With certifications such as FDA compliance and ATEX safety, and a CIP-ready design for easy cleaning, this valve is customizable to suit diverse industrial needs.

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Mixing and freeze-drying in one step

The active freeze dryer from Hosokawa Micron uses very low temperatures and a vacuum to dry your product and to obtain it in very good quality. Due to the low temperatures usage the damage of heat sensitive products, such as enzymes, flavors, proteins, vitamins and so on is avoided. Hand traditional tray-type freeze dryers are slow and labor-intensive. Hosokawa’s Active Freeze Dryer ® eliminates these drawbacks.
Typical applications include pharmaceuticals like antibiotics, collagens, APIs and electrolytes; Food industry and in special materials like nanomaterials, polymers, ceramics, pigments, fillers, limestone, catalysts, glass powder and salts.

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Ultrafine size reduction of mini-batches

The laboratory spiral jet mill, 50 AS from Hosokawa alpine is used for ultra-fine size reduction of dry materials with a crystalline structure up to Mohs hardness of three and production of a powder with a high ultra-fine portion between 0.5 and 30µm.

Often used for processing pharmaceutical active substances like parenteralia, DPIs (dry powder inhalants) and other active substances.

This compact and portable design meets the highest pharmaceutical standards and is ideal for the operation in an isolation containment device.

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Simulates Subcutaneous Injections for Formulation Testing

The SCISSOR N3 from Pion is an in vitro subcutaneous injection simulator designed for biopharmaceutical and pharmaceutical R&D. This tool accurately mimics the physiological conditions experienced by injectables, allowing you to assess drug release dynamics and optimize formulations without relying on animal models. Ideal for screening excipients and rank ordering formulations, it yields bio-relevant insights for injectable drugs, including adalimumab and insulin formulations. Compatible with optional fraction collectors and the Rainbow R6 UV-vis spectrometer, the SCISSOR N3 enables real-time, in situ data collection. It supports liquid formulations in controlled, bench-top environments, providing critical data for long-acting injectables and innovative drug delivery solutions.

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Processes and Encapsulates Liquids at High Pressure

The DeBEE 2000 from Pion is a high-pressure homogenizer designed for diverse applications within the pharmaceutical, biotech, chemical, food, and cannabis industries. It uniquely combines R&D versatility with pilot scale production capabilities, enabling effective processes such as cell disruption, particle size reduction, and nano-encapsulation. This system is ideal for creating protein therapeutics, liposomal encapsulated vitamins, and other intricate formulations, including cannabis-infused beverages. Capable of handling both liquids and slurries, the DeBEE 2000 ensures product consistency and quality with cGMP compliance and SCADA integration for real-time monitoring and control. It features a clean-in-place (CIP) system, simplifying maintenance while ensuring hygiene standards are maintained. With electronic signature compatibility and comprehensive data collection functionalities, this equipment supports stringent regulatory requirements. Pion provides customization options to meet specific production needs, backed by engineering support for seamless integration into your existing production line.

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Processes Nanoemulsions and Reduces Particle Size

The Micro DeBEE Laboratory High-Pressure Homogenizer from Pion is a versatile bench-top solution tailored for precise laboratory operations. This air-powered unit excels in processes such as cell lysis, nanoemulsions, particle size reduction, and dispersion, achieving industry-leading results with operating pressures up to 30,000 PSI. Designed for pharmaceuticals, biotech, and cosmetics, it aids in producing high-yield formulations like liposomal vaccines, protein therapeutics, and polymeric nanoparticles. With a flow rate of 15 LPH and requiring only clean, dry air for operation, it integrates seamlessly into your lab, offering no-assembly-required maintenance. Engineered for bioavailability enhancement and tighter particle distribution, it complies with laboratory standards while its small footprint and easy cleaning optimize workflow efficiency.

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Ensures Sterility and Safe Aseptic Processing

The ISOPRIME Isolators from Getinge provide a robust solution for pharmaceutical, biotech, and healthcare facilities requiring stringent sterility and contamination control. Designed with modular rigid-wall systems, the ISOPRIME excels in a range of aseptic and sterile processing applications, including compounding, aseptic filling, and sterility testing. Engineered for continuous operation, these isolators incorporate a validated Siemens PLC for reliable process control and traceability while supporting large-scale production efficiency through versatile airflow options—unidirectional or turbulent.

Suited for a diverse array of end-products like monoclonal antibodies, saline IV bags, and personalized cancer vaccines, ISOPRIME ensures compliance with FDA 21 CFR Part 11. It delivers comprehensive bio-decontamination capabilities through an integrated H2O2 generator, facilitating in-situ cleanliness and safety.

Optimized for ease of access and maintenance, the design features upward-opening doors and convenient electrical cabinet entry points, reducing downtime. Integration with Getinge’s DPTE® transfer system guarantees secure material transfer without breaking containment, while glove leak testing technology ensures operational integrity.

Constructed for resilience, ISOPRIME offers various customization options, including specific ventilation and access configurations, tailored to meet unique production line needs. It supports both liquid and solid product types, making it adaptable across laboratories and processing departments dedicated to cutting-edge medical solutions.

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